Registration Dossier
Registration Dossier
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EC number: 201-164-8 | CAS number: 78-98-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific participles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Methylglyoxal-induced DNA-protein cross-links and cytotoxicity in Chinese hamster ovary cells
- Author:
- Brambilla G, Sciaba L, Faggin P et al.
- Year:
- 1 985
- Bibliographic source:
- Carcinogenesis 6: 683-686
- Reference Type:
- publication
- Title:
- DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells
- Author:
- Marinari, U.M. et al.
- Year:
- 1 984
- Bibliographic source:
- Cell Biochem. Funct. 2 (4), 243-248
Materials and methods
- Principles of method if other than guideline:
- Alkaline Elution: Kohn, K.W.: Methods Cancer Res. 16, 291-345 (1979)
- GLP compliance:
- not specified
- Type of assay:
- other: Alkaline Elution
Test material
- Reference substance name:
- Pyruvaldehyde
- EC Number:
- 201-164-8
- EC Name:
- Pyruvaldehyde
- Cas Number:
- 78-98-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- 2-oxopropanal
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: CHO-cells
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0.5, 1.5, 4.5 mM
- Details on test system and experimental conditions:
- Alkaline Elution Assay: DNA damage and repair assay
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
