Registration Dossier
Registration Dossier
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EC number: 202-852-0 | CAS number: 100-43-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
4 -Vinylpyridine was used in early studies of the murine LLNA, and was evaluated as positive. Older data from guinea pig sensitisation tests demonstrated sensitisation.
Migrated from Short description of key information:
4VP is a dermal sensitiser. There is no data on respiratory sensitisation, Risk management measures as recommended will protect workers from sensitising effects of this substance.
Justification for selection of skin sensitisation endpoint:
4-Vinylpyridine dermal exposure resulted in increased lymphocyte proliferation in the LLNA protocol, and sensitization when tested in guinea pig protocols.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data on respiratory sensitisation.
Migrated from Short description of key information:
No data on respiratory sensitisation. As 4VP is also corrosive, risk management measures are recommended which will protect workers from inhalative exposures.
Justification for classification or non-classification
4-Vinylpyridine is classified as sensitising; protective clothing, goggles and gloves are recommended to minimize skin contact. These risk management measures also suffice to protect against skin corrosion properties. 4VP is required to be classified as corrosive to the respiratory tract. The risk management measures associated with this risk will accommodate any risk for respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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