Registration Dossier
Registration Dossier
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EC number: 202-852-0 | CAS number: 100-43-6
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance 4-vinylpyridine has not been demonstrated to be readily biodegradable, indicating the potential for persistence. Therefore, the substance may not be classified as "not P" or "not vP" based upon screening criteria. Data are not available for the definitive determination of "P"/"vP" properties, and therefore, no conclusion was made.
Screening-level data indicate that 4-vinylpyridine is not bioaccumulative and not very bioaccumulative, based on an experimentally-determined log Kowof 1.34, which is substantially below the screening criterion (log Kow≤4.5) for both “not B” and “not vB”. This screening-level indication is supported by the definitive criteria; the experimentally-determined bioconcentration factor of 96 is substantially below both the definitive criterion for B (> 2,000 L/kg) and the definitive criterion for vB (>5,000 L/kg).
The determinations that 4-vinylpyridine is “not CMR” and “not T, R48” or “Xn, R48” are definitive determinations of “not T” with respect to human health endpoints. The short-term screening-level data for aquatic toxicity (i.e., LC50(fish) = 1.04 mg/L > 0.1 mg/L) indicate that the substance is “not T” with respect to aquatic toxicity; however, this is not a definitive determination as long-term aquatic toxicity testing data are not available. Therefore, 4-vinylpyridine has been shown to be “presumably not T”.
Therefore, although a complete definitive determination cannot be made with respect to each of the three endpoints (P, vP, and T), screening level and definitive criteria indicate that the substance is potentially P, potentially vP, not B, not vB, and presumably not T. It is not necessary to have definitive criteria for all five endpoints to make the determinations as to whether the substance is “not PBT” and “not vPvB”. The determination based on screening criteria only requires that “each of the three properties persistency, bioaccumulation and toxicity need to be considered in conjunction” (Chapter R.11, “PBT Assessment”,Guidance on information requirements and chemical safety assessment, ECHA, May 2008, Section R.11.1.2.2, p. 13.
In summary, 4-vinylpyridine is not PBT (potentially P, not B, presumably not T) and is not vPvB (potentially vP, not vB).
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