Registration Dossier
Registration Dossier
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EC number: 449-360-4 | CAS number: 647828-16-8
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of the test material on reproduction to the sediment-dwelling oligochaete, Lumbriculus variegatus, was assessed. The method was based on the method of Phipps et al (1993) and draft OECD TG 218. The study was carried out under GLP. The worms (4 replicates of 10 worms) were exposed to formulated sediment spiked with the test material at concentrations of 32, 56, 100, 180, and 320 mg/kg dw (dry weight of sediment) for a period of 28 days. Reproduction, survival and dry weight data were recorded. Further sediment replicates were subject to chemical analysis of the sediment and overlying water on days 0 and 28. Analysis of the test sediments indicated that the mean concentrations were within ± 20% of nominal and therefore the results were based on nominal concentrations. The 28-d EC50 (reproduction) was 78 mg/kg dw with 95% confidence limits of 43 -120 mg/kg dw. The NOEC for reproduction was 32 mg/kg dw at which the same number of worms were seen as in the (solvent) control. The LOEC was 56 mg/kg dw at which the number of worms was similar to the number of worms at day 0, indicating absence of reproduction. At 180 and 320 mg/kg dw, the number of worms had decreased compared to day 0, indicating mortality.
Key value for chemical safety assessment
- EC10, LC10 or NOEC for freshwater sediment:
- 32 mg/kg sediment dw
Additional information
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