Registration Dossier
Registration Dossier
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EC number: 230-256-0 | CAS number: 6990-06-3
Auto flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative self-ignition temperature (solids)
- Remarks:
- Minimum ignition energy of dust clouds (MIE) and the minimum ignition temperature of dust layers (MITdl).
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009.09.05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: EN 50281-2-1 1998: Part 2-1
- Version / remarks:
- Methods for determining the minimum ignition temperature of dust
- Principles of method if other than guideline:
- Two micronized products from LEO Pharma A/S were tested at GexCon’s dust explosion test laboratory for the determination of the minimum ignition energy of dust clouds (MIE) and the minimum ignition temperature of dust layers (MITdl).
- GLP compliance:
- no
- Specific details on test material used for the study:
- Sodium fusidate
Fusidic acid - Key result
- Relative self-ignition temperature:
- > 155 °C
- Remarks on result:
- not determinable
- Remarks:
- No ignition (105-155 °C) Fusidic acid
- Key result
- Relative self-ignition temperature:
- > 350 °C
- Remarks on result:
- not determinable
- Remarks:
- No ignition (200-350 °C) Sodium fusidate
- Conclusions:
- The test results for the determination of the minimum ignition energy of dust clouds were:
Sodium fusidate: 10 -15 mJ
Fusidic acid: < 2 mJ
Sodium fusidate
Tests were performed with 5 mm layer thicknesses in the temperature ranges of 200°C - 350°C. No ignition was observed
Fusidic acid
Tests were performed with 5 mm layer thicknesses in the temperature ranges 105°C - 155°C. No ignition was observed - Executive summary:
The samples were tested in the open Hartmann apparatus for the determination of the minimum ignition energy of dust clouds.
The samples were tested using the so-called Hot Plate for the determination of the minimum ignition
temperature of dust layers. In both cases the samples were tested under atmospheric conditions.
The test results for the determination of the minimum ignition energy of dust clouds were:
Sodium fusidate: 10 -15 mJ
Fusidic acid: < 2 mJ
Results from determining the minimum ignition temperature of dust layers were
Sodium fusidate
Tests were performed with 5 mm layer thicknesses in the temperature ranges of 200°C - 350°C. No ignition was observed
Fusidic acid
Tests were performed with 5 mm layer thicknesses in the temperature ranges 105°C - 155°C. No ignition was observed
Reference
Results for minimum ignition temperature of dust layers, Sodiumfusidate.
| Thickness of dust layer | Hotplate temperature (°C) | Time to ignition or timeelapsed without ignition (min) | Max. temperature measured in the sample (°C) | Results |
|
5 |
200 |
210 |
179 |
No ignition |
|
5 |
250 |
41 |
246 |
No ignition |
|
5* |
300 |
132 |
295 |
No ignition/melted |
|
5 |
320 |
80 |
310 |
Melted |
|
5 |
350 |
105 |
335 |
Melted |
|
Results for minimum ignition temperature of dust layers, Fusidic acid
| Thickness of dust layer | Hotplate temperature (°C) | Time to ignition or timeelapsed without ignition (min) | Max. temperature measured in the sample (°C) | Results |
5 |
105 |
75 |
99 |
No ignition |
5 |
115 |
300 |
75 |
No ignition |
5 |
125 |
65 |
130 |
No ignition |
5 |
135 |
126 |
133 |
No ignition |
5* |
145 |
132 |
128 |
No ignition/melted |
5* |
155 |
55 |
157 |
No ignition/melted |
*The lowest part of the dust layer (the one that rest on the hotplate) melted. The topmost part of the
dust layer was not melted.
Description of key information
The samples were tested in the open Hartmann apparatus for the determination of the minimum ignition energy of dust clouds.
The samples were tested using the so-called Hot Plate for the determination of the minimum ignition
temperature of dust layers. In both cases the samples were tested under atmospheric conditions.
The test results for the determination of the minimum ignition energy of dust clouds were:
Sodium fusidate: 10 -15 mJ
Fusidic acid: < 2 mJ
Results from determining the minimum ignition temperature of dust layers were
Sodium fusidate
Tests were performed with 5 mm layer thicknesses in the temperature ranges of 200°C - 350°C. No ignition was observed
Fusidic acid
Tests were performed with 5 mm layer thicknesses in the temperature ranges 105°C - 155°C. No ignition was observed
Key value for chemical safety assessment
Additional information
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