Registration Dossier
Registration Dossier
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EC number: 425-380-9 | CAS number: 7397-46-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The water solublllty of diethyl-methoxyborane (DEMB) is very low (< 7.6 mg/L at 19°C), and should be considered a possible rate-limiting factor for the absorption af the compound from the gastro-intestinal tract. Solubllity might be increased by the low pH in the stomach, which then may result in an increased absorption. Because of the lipophilicity of DEMB, it is to be expected that the oral bioavailability will be higher when the compound is ingested together with food (1). DEMB is a typical borate ester. These esters are mild lewis acids and are generally rapidly hydrolysed by water. This phenomenon is also seen for DEMB. Usually, the organometallic compounds like DEMB are soluble in various inert organic solvents. Typical solvents are ethers and alkanes.
Because of the rapid decomposition in water (2), it is also expected that DEMB will be rapidly decomposed in body fluids such as the gastro-intestinal fluids. Because of the acid environment in the stomach, this reaction may even be more agressive. Consequently, besides the possible immediate toxic local effect of the decomposition reaction, the intestinal and systemic toxicity after administration of DEMB will probably be related to the reaction products methanol, formic acid and diethylboronic acid. These reaction products of DEMB are expected to be easily metabolised and excreted via urine or bile.
Since it is generally accepted that substances with log Pow ranging from 0.1 to 6 penetrate the skin easily (3), it is to be expected that DEMB will be absorbed to same extent through the skin.
Taking into account the available physico-chemical data, it is expected that DEMB will have a relatively short elimination half-life in the body.
Based on the expected kinetic behaviour in the body, as described above, OEMB will not accumulate in the body after prolonged exposure.
References
1. L.S. Schanker et al. Absorption of drugs from the rat small intestine. J. Pharmacol. Exp. Ther. 123 (1958) pp 81 -88.
2. A. Streitwieser and C.H. Heathcock. Introduction to organic chemistry. MacMillan Publishing Co., New York, 1976, p. 286
3. T.G. Vermeire et al., Estimation of consumer exposure to chemicals: application of simple models. The Science of the Total Environment 136 (1993) 155-176.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
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