Registration Dossier
Registration Dossier
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EC number: 201-983-0 | CAS number: 90-30-2
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
The key endpoint was based on the 14d LD50 of 2690 mg/kg of bodyweight (Colinus virginianus) reported in study with a structurally analogous compound (naphthalene). In order to convert to an equivalent concentration in food, a standard conversion factor (8) was applied in accordance with ECHA R.10. The resulting LC50 was 21520 mg/kg food.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 21 520 mg/kg food
Additional information
No data are available for the toxicity of N-phenyl-1-naphthylamine to terrestrial organisms. Therefore, information from a supporting, structurally analogue compound (naphthalene) was taken into account.
In the key study, the effect of naphthalene (purity unknown) on Colinus virginianus was tested according to an EPA guideline on Hazard Evaluation regarding wildlife and aquatic organisms. Nominal concentrations of 0, 292, 486, 810, 1350 and 2250 mg/kg were added to the daily feed. The effect on behaviour and survival of the approx. 7 month old birds was determined as LD50(14d) of 2690 mg/kg bw/day (mortality) (confidence limits 1571-57063 mg/kg bw/day). From 2250 mg/L, signs of lethargy, depression, reduced reaction to external stimuli (sound and movement), loss of coordination, lower limb weakness and ruffled appearance were recorded.
A supporting study on the effects of naphthalene on 13-day old specimens of Colinus virginianus showed no mortalities at any concentration tested (0, 316, 562, 1000, 1780, 3160 and 5620 mg/L). There was a slight reduction in body weight observed at 1780 mg/L and above which is why a NOEC(5d) = 1000 mg/kg bw/day was determined as well as a LC50(5d) > 5620 mg/kg bw/day.
The key endpoint was based on the 14d-LD50 of 2690 mg/kg of body weight. In order to convert to an equivalent concentration in food, a standard conversion factor (8) was applied in accordance with ECHA R.10. The resulting LC50 was 21520 mg/kg food.
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