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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Principles of method if other than guideline:
TIMES AMES model predictions and Toolbox read-across analyses
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
EC Number:
292-054-9
EC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Cas Number:
90530-16-8
IUPAC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Remarks:
QSAR prediction
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: other: QSAR
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative Not classified as mutagen.

Not classified as mutagen.
Executive summary:

Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, theUVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.