Registration Dossier
Registration Dossier
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EC number: 292-054-9 | CAS number: 90530-16-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: QSAR, read-across
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- TIMES Skin irritation/corrosion predictions and QSAR Toolbox read-across predictions
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- EC Number:
- 292-054-9
- EC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- Cas Number:
- 90530-16-8
- IUPAC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: QSAR, read-across
- Basis:
- other: QSAR, read-across
- Remarks on result:
- other: QSAR and read-across
- Irritant / corrosive response data:
- • The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C.
Any other information on results incl. tables
· The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:
- ConstituentsMXDA, A and C:Corrosive to skin;
- Constituents B and D:Irritating to skin;
- Constituent E:Non-irritating/corrosive to skin.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Migrated information H314 Criteria used for interpretation of results: EU
- Conclusions:
- The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C. (H314)
- Executive summary:
· The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:
- ConstituentsMXDA, A and C:Corrosive to skin;
- Constituents B and D:Irritating to skin;
- Constituent E:Non-irritating/corrosive to skin.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.
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