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EC number: 218-542-3 | CAS number: 2177-70-0
Endpoint summary
Administrative data
Description of key information
Additional information
Freshwater aquatic toxicity studies with PHMA were conducted in invertebrates, algal and microbial species.
Short-term toxicity to aquatic invertebrates
The 48 h acute toxicity of PHMA to Daphnia magna was studied under static-renewal conditions (renewal after 24 h) according to OECD guideline 202 (2004). Daphnids were exposed to control and test chemical at nominal concentration of 0 (control), 0.625, 1.25, 2.50, 5.00 and 10.0 mg/L, corresponding to measured (geometric mean) 0, 0.534, 1.07, 2.13, 4.42 and 8.98 mg/L. Mortality/immobilisation was observed daily.
The 48 h EC50 based on measured (geometric mean) concentrations was 4.03 mg/L (95% c.i.3.83 - 4.23mg/L).
Toxicity to aquatic algae
In a 72 hour acute toxicity study, the cultures ofDesmodesmus subspicatusCHODAT SAG 86.81 were exposed to PHMA at concentrations of nominal 0 (control), 1.00, 3.16, 10.0, 31.6 and 100 mg/L, corresponding to measured (geometric mean) 0, 0.472, 1.90, 7.31, 25.5 and 79.8 mg/L under static conditions in accordance with the OECD guideline 201 (adopted 23 March 2006).
Microscopic evaluation of the cells at start and end of the incubation period revealed no morphological abnormalities.
The NOEC-values, EC10-values with 95% confidence intervals and EC50-values with 95% confidence intervals for inhibition of growth rate after 72 hours were 1.90 mg/L, 5.19 (3.72 - 6.37) and 8.72 (7.95 - 12.6), respectively. All effect levels are given based on geometric mean measured concentrations of PHMA.
Toxicity to microorganisms
The toxicity of PHMA (99.6% a.i.) to microorganisms was investigated during a ready biodegradation study according to OECD guideline 310 (Headspace Test), adopted 23 March 2006, over a period of 28 days and using predominantly domestic non-adapted activated sludge as inoculum. The biodegradation rate was determined by measurement of carbon dioxide evolution.
Inoculum blank, procedural/functional control with the reference substance Sodium benzoate and toxicity control with reference substance and test substance (20 mg/L test substance) were performed.
The biodegradation in the toxicity control reached 87% within 14 days and came to 81% after 28 days. The biodegradation of the reference item was not inhibited by the test item.
Therefore, the test substance was assumed not to inhibit microbial activity at a concentration of 20 mg/L.
In conclusion, the lowest aquatic toxicity value for PHMA was the 48 h-EC50 of 4.03 mg/L, based on the toxicity test with the freshwater invertebrate Daphnia magna.
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