Registration Dossier
Registration Dossier
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EC number: 619-721-2 | CAS number: 1079258-99-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Data from the structurally related substance " Silsesquioxanes, 3-phosphonopropyl, Et Me esters, sodium salts" (CAS 225375-65-5) was used to assess the aquatic toxicity of the registration item ( Phosphonic acid, P-(3-silylpropyl)-, Si,Si,Si-tris(mixed ethoxy and methoxy) derivs., mixed Et and Me diesters; CAS 1079258-99-3):
The read across substance Silicophosphonat was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains, i.e. Salmonella typhimurium and Escherichia coli, in a reverse mutation assay (OECD 471 guideline and GLP, BASF, 2008).
STRAINS: TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA
DOSE RANGE: 60 μg – 15 000 μg/plate (SPT) 937.5 μg – 15 000 μg/plate (PIT)
TEST CONDITIONS: Standard plate test (SPT) and preincubation test (PIT) both with and without metabolic activation (induced rat liver S9 mix).
SOLUBILITY: No precipitation of the test substance was found.
TOXICITY: A bacteriotoxic effect was observed depending on the test conditions at 15 000 μg/plate (for details see item 4.2.). MUTAGENICITY: An increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S9 mix or after the addition of a metabolizing system.
CONCLUSION: According to the results of the present study, the read across substance Silicophosphonat is not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay under the experimental conditions chosen here.
Short description of key information:
Ames-Test (read across): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available read across data, no classification for mutagenicity is warranted.
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