Registration Dossier
Registration Dossier
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EC number: 619-721-2 | CAS number: 1079258-99-3
Endpoint summary
Administrative data
Description of key information
LD50(oral, rat) > 2000 mg/kg (BASF, 2015)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute oral toxicity
In an acute oral toxicity study (BASF, 2015) performed according to the Acute Toxic Class method (OECD 423 guideline and GLP), 2000 mg/kg bw of the undiluted test item Diethylphosphonatopropyltrimethoxysilan were administered by gavage to two test groups of three fasted Wistar rats each (6 females). The following test substance-related clinical observations were recorded, clinical signs occurred within the first day after administration:
2000 mg/kg (first test group):
- No mortality occurred
- Impaired general state in all animals
- Dyspnoea in all animals
- Piloerection in all animals
- Cowering position in all animals
- Reduced defecation in one animal
2000 mg/kg (second test group):
- No mortality occurred
- Impaired general state in all animals
- Piloerection in all animals
The body weight of all animals increased within the normal range throughout the study period with two exceptions in the second 2000 mg/kg bw test group. In two animals the body weight increased within the normal range during the first week, but stagnated during the second week. This effect is observed at times in the rat strain used, because in the required age range the female animals have already reached the phase of slow growth. There were no macroscopic pathological findings in the animals which were sacrificed at the end of the observation period (6 females). The acute oral LD50 was calculated to be LD50, oral, rat > 2000 mg/kg bw
Justification for classification or non-classification
No classification for acute oral toxcity is required based on the available acute oral toxicity study.
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