Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 930
- Report date:
- 1930
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- methyl acrylate, not further specified
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Duration of treatment / exposure:
- up to 5 injections / week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50; 100; 200; 300; 400; 500 mg/kg bw; in an "oily solution"
- No. of animals per sex per dose:
- 50 - 400 mg/kg bw: 1 animal per dose
500 mg/kg bw: 2 animals - Control animals:
- no
- Details on study design:
- Post-exposure period: not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Mortality and clinical signs:
500 mg/kg: lethal for 2 animals after the first injection
(time to death: 4 hours to 1 day), clinical signs:
convulsions, irregular breathing, lateral position.
400 mg/kg: lethal after second injection; no specific
clinical signs after first injection (hyperactivity),
convulsions after 2nd injection.
300 mg/kg (2 injections): no mortality, no clinical signs
200 mg/kg (3 injections): no mortality, no clinical signs
100 mg/kg (5 injections): no mortality, no clinical signs
50 mg/kg (5 injections): no mortality, no clinical signs
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
