Scale (coating), copper

Eye irritation

Administrative data

Endpoint:

eye irritation

Remarks:

other: calculation software

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: software

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

The potential of the UVCB substance to be eye irritant was established by classifying the complex metal substance based on Mixture rules from EU CLP (summation and/or additivity of classified components to derive Hazard class). The classification criteria (as set out in EU CLP Guidance Annex I: 3.3.2.2 pg 247) can be used to estimate effects.

GLP compliance:

no

Remarks:

other quality assurance

Test material

Test material information

Constituent 1

Reference substance name:

Scale (coating), copper

EC Number:

273-744-9

EC Name:

Scale (coating), copper

Cas Number:

69012-45-9

IUPAC Name:

scale (coating), copper

Details on test material:

Typical and Worst case across industry as defined in IUCLID 1.2 for Grade 1 and Grade 2, 3 and 4 respectively ;
See IUCLID Section 1.4, for company specific elemental composition; and representative sample for mineralogical information (IUCLID Section 4.23 -Outotec report).

Results and discussion

In vivo

Irritant / corrosive response data:

irritant (estimated response)

Any other information on results incl. tables

The calculated classification via Additivity method resulted in "Serious eye damage / eye irritation: category 2 H319”, driven by Cu(I) species (cat 2 eye irritant) that, in both Grades, can be present in amounts > than 10%.

Applicant's summary and conclusion

Interpretation of results:

Category 2A (irritating to eyes)

Remarks:

Migrated information predicted effect Criteria used for interpretation of results: EU

Conclusions:

Study can be used to establish eye irritation/serious eye damage potential of the UVCB substance.

Executive summary:

The study provided an estimate of the Eye Irritation/serious eye damage effect, derived on basis of the Classification outcome (Mixture toxicity rules) from a typical across industry as defined in IUCLID section 1.2/1.4/4.23.

The result is applicable to Grade 1 and Grade 2, 3 and 4 Copper scales that fall under the defined concentration ranges (IUCLID section 1.2).

The result is furthermore supported by (WoE) consideration from chemical & mineralogical information (IUCLID 4.23) showing that significant amount of Eye Irritant/corrosive Cu(I) species could be detected in representative samples of both grades (for Grade 2, Total Cu >80% were considered).

Water solubility test furthermore confirmed that the UVCB has low solubility, except for Si, Na, K, Ca and Cu where these constituents/species solubilised (at high loading of 5g/100ml and after ca. 14 -16 days) -with pH observed remaining at ca 9 or ca 7 (ie not exceeding to extremes <2 or >11,5).