Registration Dossier
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EC number: 202-951-9 | CAS number: 101-54-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The chronic toxicity of 4-ADPA to aquatic invertebrates (Dapnia magna) was conducted in a semistatic reproduction test according OECD Guideline for Testing of Chemicals 202, part II, 04. April 1984. After 21 days of exposure a NOEC-reporduction of 0.04 mg/l (nominal), LOEC-reproduction of 0.13 mg/l (nominal), EC50-reproduction of 0.1 mg/l (nominal) and EC50-imboilisation of 0.52 mg/l (nominal) were determined (Bayer, 1992).
Key value for chemical safety assessment
Additional information
The analytical monitoring showed that at the nominal NOEC (reproduction) of 0.04 mg/l, 4-ADPA decreased significantly during 3 h of stirring in an open beaker to 38 % (0.015 mg/l) before the start of the experiment and subsequently during the incubation period to less than the determination limit of 0.01 mg/l. According to the stability in water study from BIS 2004, the fast lost of 4-ADPA during the preparation period of only 3 hours cannot be only up to abiotic degradation alone. The adsorption of 4 -ADPA at low concentrations to glass wall can be also a reason.The similar effect has been observed before in inherent biodegradability test from Bayer 1989 (Currenta,2009). Unfortunately, not all of the nominal concentrations were confirmed analytically at the starting point of the experiments, and hence statistical analyses based on measured results were not posssible. Consequently, nominal concentrations were used to calculate EC50, NOEC and LOEC.
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