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EC number: 215-149-9
CAS number: 1306-25-8
A Short-term reproductive and developmental toxicity screen test
(28days)with 10 Sprague-Dawley rats/sex/dose was conducted. A pilot
dose-range-finding study found hematology, clin chem, and body/organ
weight effects at the lowest level (100 mg/kg/d); main study doses were
set at 10, 30, and 100 mg CdTe/kg/d, p.o. in 0.5% methylcellulose. Food
consumption was variably decreased (less than or equal to 18%) at 30 and
100 mg/kg. All dosed males gained less weight; the high dose group lost
23 gr (3.7% body wt). Relative kidney weight was increased; male liver
and spleen wts and all reproductive indices (fertility, sperm #,
motility) were unchanged. CdTe did not alter the number of live
implants, resorptions or corpora lutea in females treated
before/during/after cohabiting with treated males, although body wt gain
was inhibited by CdTe (less than or equal to 50%). Another group of
females was dosed GD 6-15 only, and delivered their litters; all were
killed pnd4. There was a dose-related decrease in dam body wt in all
CdTe groups (on pnd1, less than or equal to 15%), with no change in the
number of live pups delivered, postnatal deaths or pup wt at or after
These data show that, despite effects on body wt gain, this
duration of CdTe dosing had no detectable effects on male or
female rat reproduction or early embryo development.
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