Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-149-9
CAS number: 1306-25-8
Cumulative exposure index (µg/m3.years)
Smoking (cigarettes/day x years)
Cd-B (µg:100 ml)
- FVC, FEV1,
TLCO and KCO observed in cadmium-exposed workers were not significantly
different from controls:
Percent of controls (%)
100.2 (± 12.1)
98.6 (± 13.8)
99.9 (± 17.5)
values of residual volume were however moderately higher in exposed
subjects as compared with those in the control group (+ 8.6%) and the
difference was statistically significant.
Cumulative exposure index (µg/m3. years)
Variation in residual volume (RV)
108.6 (± 24.1)*
107.3 (± 24.2)*
110.2 (± 24.4)*
Dose - response curve :
The effect on RV was greater (+ 10%)
in the subgroup of workers with greater cumulative exposure to cadmium.
Cortona et al. (1992) measured
respiratory function parameters in 69 smoking and nonsmoking
male subjects (average age 45) who were exposed to
concentrations of 0.008–1.53 mg/m3 of cadmium fumes over a
period of several years in a factory that produced cadmium
alloys (silver-cadmium-copper). Forced Expiratory Volume
(FEV), Forced Vital Capacity (FVC), Residual Volume (RV),
Transfer Factor by the carbon monoxide method (TLCO), and
Transfer Coefficient (KCO) were measured in these exposed
The study found that there were no
significant differences in the FVC, FEV, TLCO, and KCO between
the workers exposed to cadmium fumes and control (non-exposed)
individuals. There was a significant increase in RV of >8% in
exposed workers; this effect was notably greater in those with
higher cumulative exposures to cadmium (>10%). It is uncertain
how much of a factor on the increased RV was due to the
tendency of smokers to develop an initial emphysematous
alteration in lung tissue due to smoking.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again