Registration Dossier
Registration Dossier
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EC number: 234-679-1 | CAS number: 12023-27-7
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
The study on toxicity to microorganisms with diiron titanium pentaoxide does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur (study scientifically not necessary). However, by applying an analogue approach the EC50 for the target substance was determined to be 1000 mg/L, respectively.
Long-term toxicity to fish
The study does not need to be conducted as the substance is highly insoluble in water and unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur. This conclusion is supported by assessments for the structural analogues diiron trioxide (CAS 1309-37-1) and titanium dioxide (CAS 13463-67-7) demonstrating that long-term toxicity to fish is not to be expected. Therefore, generating additional data is scientifically not justified.
Short-term toxicity to aquatic invertebrates
The study on short-term toxicity to aquatic invertebrates with diiron tetanium pentaoxide does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur (study scientifically not necessary). However, by applying an analogue approach the 48-hour EC50 for the target substance was determined to be >= 100 mg/L.
Long-term toxicity to aquatic invertebrates
The study does not need to be conducted as the substance is highly insoluble in water and unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur. This conclusion is supported by assessments for the structural analogues diiron trioxide (CAS 1309-37-1) and titanium dioxide (CAS 13463-67-7) demonstrating that long-term toxicity to aquatic invertebrates is not to be expected. Therefore, generating additional data is scientifically not justified.
Toxicity to aquatic algae and cyanobacteria
The study on toxicity to aquatic algae and cyanobacteria with diiron titanium pentaoxide does not need to be conducted as the substance is highly insoluble in water and unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur. However, by applying an analogue approach the 72-hour EC50 and NOEC for the target substance were determined to be > 100 mg/L, respectively
Toxicity to microorganisms
The study on toxicity to microorganisms with diiron titanium pentaoxide does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur (study scientifically not necessary). However, by applying an analogue approach the EC50 for the target substance was determined to be 1000 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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