Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-679-1 | CAS number: 12023-27-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with column 2 of Annex IX to Regulation (EC) No 1907/2006 (REACH) the study on bioaccumulation potential does not need to be conducted because the substance has a low potential to cross biological membranes.
Key value for chemical safety assessment
Additional information
Diiron titanium pentaoxide is an inorganic substance and deriving a partition coefficient octanol/water (log Kow) is thus technically not feasible (please see IUCLID section 4.7). However, based on the chemical structure of the substance, and despite the fact that it is sparingly soluble in water, the log Kow is expected to be below the trigger value of 3 given in column 2 of Annex IX to Regulation (EC) 1907/2006 (REACH). Furthermore, the maximum of the mono-modal particle size distribution was observed at approximately between 10 µm and 20 µm. The D10, D50 and D90 percentile were determined as L10 = 7.07 µm, L50 = 13.1 µm and L90 = 22.9 µm, respectively. Considering these physicochemical properties, diiron titanium pentaoxide is very unlikely to cross biological membranes (please also refer to IUCLID section 7.1).
Moreover, to the current state of scientific knowledge, a clear interpretation of the significance of bioaccumulation measures (e.g. BCF, BAF) for metal-containing inorganic substances is not possible. But also in silico models such as BCFWIN (as implemented in the US EPA EPI Suite) are not suitable for the prediction of the bioaccumulation potential of metal-containing inorganic substances (Adams WJ and Chapman PM, 2007).
Therefore, this endpoint was waived.
Reference: Adams WJ and Chapman PM. 2007. Assessing the hazard of metals and inorganic metal substances in aquatic and terrestrial systems. SETAC Publications, CRC Press. Chap 4: 55-87. Cited in: OECD SIDS Report on titanium dioxide (OECD, 2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
