Registration Dossier
Registration Dossier
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EC number: 231-723-1 | CAS number: 7704-67-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: Test method similar to OECD 211. No data on GLP. The NOEC after 21 days of exposure of Daphnia magna to erythromycin thiocyanate was determined to be 248 µg/L.
Weight of evidence: Test method similar to OECD 211. No data on GLP. The NOEC after 21 days of exposure of Daphnia magna to erythromycin thiocyanate was determined to be 179 µg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.179 mg/L
Additional information
Weight of evidence:
Toxicity of erythromycin thiocyanate (ET) to Daphnia magna was evaluated in a flow-through test method, Continuous Exposure Test System, similar to OECD 211. Seven <24h old Daphnids per group were exposed to the erythromycin thiocyanate in a concentrations of0, (control), 0.60, 300 and 3,000 µg/L of ET and a mixture of 62 µg/L DH (Diphenhydramine hydrochloride): 300 µg/L ET for a exposure period of 21 days. Analytical monitoring was performed. Mortality, the lenght of survivings at the end of the trial, days of first brood and the number of broods and youngs produced were analysed. Based on the obtained results, the no observable effect concentration (NOEC) was determined to be 248 µg/L.
Weight of evidence: Toxicity of erythromycin thiocyanate toDaphnia magnawas evaluated in a flow-through test method, Continuous Exposure Test System, similar to OECD 211. Ten <24h old Daphnids per group were exposed to Relative to 0 (control), 200, 400, 800 and 1600 µg/L of erytrhomycin thiocyanate for a 21 days exposure. Relative to the control treatment group, Daphnia magna survival and production, specifically the number of broods and total number of young produced, were significantly impacted during 21 days of continuous exposure to erythromycin thiocianate at concentrations higher than 179 µg/L. The NOEC for the test substance was determined to be 179 µg/L.
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