Registration Dossier
Registration Dossier
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EC number: 209-708-6 | CAS number: 591-22-0
Endpoint summary
Administrative data
Description of key information
Using an in vitro protocol, the substance is irritating but noncorrosive, but in an in vivo protocol, the substance was corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are conflicting test results for the irritation/corrosion of 3,5-dimethylpyridine. In an in vitro test, the OECD 435 barrier method (Corrositex) indicated that the substance was not corrosive but was irritating. In contrast, in an in vivo test where the substance was placed on the skin of rabbits for 4 hours under a semiocclusive bandage, the substance caused skin burns and was categorized as corrosive. In neither study was the purity of the substance provided nor compared with that of the current commercial product. No data were provided in the Corrositex study concerning the behaviour of the substance in the color detection system (CDS) associated with identification of corrosive chemicals; data was provided only for the CDS used for chemicals classified as "irritating". The in vivo study warrants a higher weight of evidence than the in vitro cell-free study. The substance is classified as corrosive.
Justification for selection of skin irritation / corrosion endpoint:
Experiment result in vivo
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
The substance causes corrosion within 4 h of application to the skin of rabbits. This qualifies as Category 1 under Regulation EC No. 1272/2008.
Based on the finding of corrosion in the skin irritation/corrosion study, an eye irritation study was not undertaken. The substance is classified as Category 1, causes serious eye damage, based on the recommendation by ECHA in Section 3.3 of Guidance on the Application of the CLP Criteria, Version 2, 27 April 2012, that eye damage is implicit for substances classified as skin corrosive category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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