3,5-dimethylpyridine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Experimental study performed in a reliable industry laboratory.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

no follow-up study at lower doses

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,5-dimethylpyridine

EC Number:

209-708-6

EC Name:

3,5-dimethylpyridine

Cas Number:

591-22-0

Molecular formula:

C7H9N

IUPAC Name:

3,5-dimethylpyridine

Constituent 2

Reference substance name:

3,4-dimethylpyridine

EC Number:

209-511-5

EC Name:

3,4-dimethylpyridine

Cas Number:

583-58-4

IUPAC Name:

3,4-dimethylpyridine

Test material form:

other: liquid

Details on test material:

Source: Sigma-Aldrich (commercial vendor). No data on purity. Lot #L420-6. Described as a clear liquid, pH approximately 5.

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

female

Details on test animals or test system and environmental conditions:

Two female Fisher 344 rats had their fur clipped approximately 24 h prior to doisng. The animals received a single dermal exposure to 2000 mg/kg bw of neat test material.

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

No information was provided on the wrapping of the dermal site after dosing. In another part of the same study, sites receiving dermally-applied material were wrapped in a semiocclusive bandage. In another part of the same study, animals were observed for 14 days after dosing.

Duration of exposure:

not relevant

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

2 females

Control animals:

no

Results and discussion

Preliminary study:

Both animals died within one hour of dosing.

Effect levels

Sex:

female

Dose descriptor:

LD100

Effect level:

< 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: All animals died at this dose.

Mortality:

All animals died within 1 hour of dosing.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information LD50 is less than 2000 mg/kg bw. Criteria used for interpretation of results: EU

Conclusions:

The LD50 of dermally-applied 3,5-dimethylpyridine in rats is less than 2000 mg/kg bw. The substance is classified as Category 4 according to Regulation EC No. 1272, 2008.