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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study follows international guidelines and it has been performed in GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Reaction products of metal-free bottom ash from municipal solid wastes incineration with water and with or without lime
EC Number:
939-997-0
IUPAC Name:
Reaction products of metal-free bottom ash from municipal solid wastes incineration with water and with or without lime
Test material form:
other: liquid slurry
Details on test material:
The substance is marketed as slurry (water content up to 60%) or as granular solid (water content up to 25%). The dry form is solid.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
other: The test item was held in contact with the skin by a dressing. The dressing consisted of a gauze-dressing and non-irritating tape and was fixed with an additional dressing in a suitable manner.
Vehicle:
other: none
Duration of exposure:
24 h
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Other findings:
No specific findings during the whole observation time.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 of the substance in rats was > 2000 mg/kg bw.