Registration Dossier
Registration Dossier
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EC number: 700-518-3 | CAS number: 38233-76-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 December 2010 - 10 December 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD test guidelines, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431: OECD Guideline for the Testing of Chemicals, In Vitro Skin Corrosion: Human Skin Model Test, 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (3R,6S,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene; (3S,6R,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene
- EC Number:
- 700-518-3
- Cas Number:
- 38233-76-0
- Molecular formula:
- C14H18
- IUPAC Name:
- (3R,6S,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene; (3S,6R,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene
Constituent 1
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µL
- Concentration (if solution): N/A - Applied as neat substance. - Duration of treatment / exposure:
- 3 minutes and 1 hour.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: Tissue viability (% of mean negative control)
- Value:
- 103.1
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 3 Minutes. Max. score: 100.0. Reversibility: no data. Remarks: Prediction: non-corrosive.. (migrated information)
- Irritation / corrosion parameter:
- other: other: Tissue viability (% of mean negative control)
- Value:
- 94.4
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 1 Hour. Max. score: 100.0. Reversibility: no data. Remarks: Prediction: non-corrosive. (migrated information)
Any other information on results incl. tables
Negative control
The mean optical density of each duplicate negative control value for the three minute and one hour contact were 1.512 and 1.544, respectively. Both values were above the minimum assay acceptance value of 0.8.
Positive control
The mean relative tissue viability of the positive control, 8.0 N potassium hydroxide, for the one hour application was 5.7%. This value was below the maximum acceptable value of 15%.
Applicant's summary and conclusion
- Conclusions:
- ETD was predicted non-corrosive.
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