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EC number: 420-380-5
CAS number: 136465-81-1
Following test guideline compliant dermal application of
PTH-decahydroamide for 24 hours, at 2000 mg/kg bw, to a group of five
male and five female Wistar rats, two of the males died within an hour
of completion of the topical exposure. Other effects noted included
lethargy for several males and females on days 1 and/or 2; erythema,
scabs and desquamation for one or two females from Day 5 and
erythematous reactions persisting to termination for one female. Low
bodyweight gains were recorded for several rats in the first week but
gains were normal during the second observation week. Necropsy of the
decedents and the rats surviving to Day 15 revealed no macroscopic
abnormalities. The median lethal dermal dose in both sexes exceeded 2000
mg/kg bw and consequently PTH-Decahydroamide does not require
classification for dermal toxicity according to the criteria laid out in
Commission Regulation (EC) No. 1272/2008.
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