Registration Dossier
Registration Dossier
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EC number: 939-509-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene is a multiconstituent substance containing
(611 -06 -3) 2,4 -Dichloronitrobenzene : 50 -80 %
(601 -88 -7) 2,6.-Dichloronitrobenzene: 10 -50 %
(89 -61 -2) 2,5 -Dichloronitrobenzene 0 -5 %
(541 -73 -1) 1,3 Dichlorobenzene 0 -<1 %
mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene 0 -10 %
SKIN SENSITISATION
611 -06 -3 GPM-test 5% intradermal 20/20 animals positiv and
541 -73 -1 : LLNA EC3 = 2.04 : sensitizing to the skin
89 -61 -2 :not sensitizing
no data available on the other constituents of the reaction mixture of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene
OVERALL CONCLUSION
Based on the available data of the test for skin sensitizing properties of the constituents of the reaction mixture of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene, especially considering the main constituent 2,4 -dichloronitrobenzene, the reaction mixture has to be evaluated as skin sensitizing
Migrated from Short description of key information:
Based on the available data of the test for skin sensitizing properties of the constituents of the reaction mixture of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene, especially considering the main constituent, the reaction mixture of 2,4 -dichloronitrobenzene and 2,6- dichloronitrobenzene has to be evaluated as skin sensitizing.
Justification for classification or non-classification
Based on the available data of the test for skin sensitizing properties of the constituents of the reaction mixture of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene, especially considering the main constituent 2,4 -dichloronitrobenzene, the reaction mixture of 2,4 -dichloronitrobenzene and 2,6- dichloronitrobenzene has to be allocated to Category 1 of skin sensitizing substances.
No subcategory (A or B) can be allocated to the the reaction mixture according to Regulation (EC) 1272/2008 (GHS, 2.ATP) and the reaction mixture will be allocated to category 1 without sub-category. Based on the weak sensitising activity of 2,4 dichloronitrobenzene and 1,3 -dichlorobenzene (both allocated to Cat1B) only a weak sensitizing property of the reaction mixture
of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene is assumed
According to Regulation 67/548/EWG the reaction mixture of 2,4 -dichloronitrobenzene and 2,6 -dichloronitrobenzene has to be classified as Skin sensitizer and labelled with R43.
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