Registration Dossier
Registration Dossier
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EC number: 939-509-6 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP defined
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dichloro-4-nitrobenzene
- EC Number:
- 210-248-3
- EC Name:
- 1,3-dichloro-4-nitrobenzene
- Cas Number:
- 611-06-3
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 2,4-dichloro-1-nitrobenzene
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- abraded
- Vehicle:
- water
- Controls:
- other: The untreated flank of each animal served as control
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 7 d
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0.55
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Irritation/corrosion score= 0.65
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Other effects:
- no data
Any other information on results incl. tables
Summary of results:
| Time after patch removal | Skin irritation/corrosion animal No. | |||||
| 7 | 8 | 9 | summ | media | ||
| Erythema | 1 h | 1 | 0 | 1 | - | - |
| 24 h | 0 | 1 | 1 | 2 | 0.7 | |
| 48 h | 0 | 1 | 1 | - | - | |
| 72 h | 0 | 0 | 1 | 1 | 0.3 | |
| End of experiment | 0 | 0 | 0 | - | - | |
| Edema | 1 h | 0 | 0 | 0 | - | - |
| 24 h | 0 | 1 | 0 | 1 | 0.3 | |
| 48 h | 0 | 0 | 0 | - | - | |
| 72 h | 0 | 0 | 0 | 0 | 0 | |
| End of experiment | 0 | 0 | 0 | - | - | |
Applicant's summary and conclusion
- Executive summary:
In a skin irritation/corrosion study according to OECD 404 3 rabbits were treated with 0.5 g of test substance fixed to the right flank of each animal for 4 h. The observation period was 7d. The untreated flank served as control. Very slight erythema and in one animal a slight and reversible edema was observed. The irritation-value was 0.65 and therefore the test substance was found to be not irritating.
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