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EC number: 411-370-1
CAS number: 82857-68-9
GM 102 E
marrow micronucleus assay was conducted in Sprague-Dawley rats according
to the micronucleus test in order to assess the in vivo genotoxicity
of GM102E. The study was conducted to a standard OECD guideline and in
compliance with good laboratory practices. Animals (15 males and females
per test substance dose and negative control) were treated by gavage
with the test substance at 50 mg/kg bw in deionized water in a single
administration. The positive control, Mitomycin C, was administered
intraperitoneally to 5 males and 5 female.
cells were harvested at 18-hour, 42 -hour and 66 -hour post-treatment.
There is no significant difference between the micronucleus frequency in
the treated group in comparison with the control group at any sampling
time. The group of animals treated with the positive control, Mitomycin
C, showed a statistically increased frequency of micronucleated cells in
comparison with the control group. Under the conditions of the in vivo
test, the registered substance showed no evidence of causing chromosome
damage or bone marrow cell toxicity.
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