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EC number: 232-088-3
CAS number: 7785-84-4
It is noted that the mean mass median
aerodynamic diameter (MMAD) exceeds the range given in test guidelines
(1-4 μm). This deviation is due to the physical characteristics of the
test item. During the characterisation phase of the study various
techniques were employed in order to try and reduce the achievable MMAD,
these included grinding the test item in a planetary ball mill and
adding particle separation devices into the generation system in order
to try and remove larger particles. During the characterisation phase of
the study the test atmosphere concentration was reduced to 2 mg/L in an
attempt to achieve a particle size as close to 4 μm as possible. This
did reduce the particle size slightly but it wasn’t considered to be
significant. It was, therefore, preferable to expose the animals to a
higher concentration of test item, even though this also increased the
MMAD, as this resulted in the animals being exposed to the highest
possible concentration of particles.
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