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EC number: 232-088-3
CAS number: 7785-84-4
To study metabolism and urinary
excretion of sodium trimetaphosphate, sodium tripolyphosphate, and
sodium hexaphosphate, these substances were administered to rabbits.
Subsequently, animals were placed in metabolic cages, blood and urine
samples were obtained and analysed on orthophosphates and
acid-hydrolysable phosphates called ‘labile phosphates’.
After intravenous injection of 249
mg/kg bw trisodium trimetaphosphate into rabbits, plasma concentration
of polymeric (‘labile’) phosphate declined almost exponentially. At best
a slight increase in serum orthophosphate concentration (resulting from
metaphosphate hydrolysis) was visible. Urinary excretion followed the
decline in serum phosphate quite well, the vast majority of
metaphosphate was excreted unhydrolysed. Alltogether, about 60% of the
administered dose was excreted in urine within 3h.
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