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EC number: 232-088-3 | CAS number: 7785-84-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The hydrolysis and excretion of polymeric phosphate
- Author:
- Gosselin RE, Rothstein A, Miller GJ, Berke HL
- Year:
- 1 952
- Bibliographic source:
- J Pharmacol Exp Ther.; 106(2):180-92; PMID: 12981640
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Metabolism and urinary excretion of sodium trimetaphosphate, sodium tripolyphosphate, or sodium hexaphosphate were studied in rabbits. To this purpose, the phosphates were injected intravenously and the animals then placed in metabolic cages. Blood samples and urine were obtained and analysed on orthophosphates and acid-hydrolysable phosphates called ‘labile phosphates’.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
Test material
- Reference substance name:
- Trisodium trimetaphosphate
- EC Number:
- 232-088-3
- EC Name:
- Trisodium trimetaphosphate
- Cas Number:
- 7785-84-4
- Molecular formula:
- H3O9P3.3Na or O3P3.3Na
- IUPAC Name:
- Sodium trimetaphosphate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Trimetaphosphate
- Analytical purity: no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 18-24h
- Individual metabolism cages: yes
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- water
- Details on exposure:
- intravenous exposure
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25.2 mg phosphorus/kg bw equiivalent to 249 mg/kg bw trisodium trimetaphosphate
- No. of animals per sex per dose / concentration:
- one animal
- Control animals:
- yes, concurrent no treatment
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- After intravenous injection of trisodium trimetaphosphate, the compound was rapidly removed from the plasma at rates which were approximately exponential. The compound produced no changes in the serum concentration of orthophosphate until late in the experiment, when a small upward trend was noted.
- Details on excretion:
- During water diuresis of rabbits, excretion of orthophosphate remained relatively constant; labile phosphorus was generally not detectable during these control periods.
After injection of trisodium trimetaphosphate, the compound appeared promptly in the urine, but after three hours, only small amounts were detectable, in conformity with plasma concentrations. The total amount excreted within 3 hours is about 60% of the injected dose. The excretion of orthophosphate also rose following the injections from 23 µg/min to 83, 56, and 44 µg/min in three 20 min intervals, suggesting a hydrolytic metabolism of the metaphosphate. No more than 2 % of the administered polymer could be detected as extra orthophosphate in the urine, the vast majority appeared as labile (presumably polymeric) phosphate.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The only metabolite arising from sodium trimetaphosphate metabolism was the orthophosphate anion.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
After intravenous injection of 249 mg/kg bw trisodium trimetaphosphate into rabbits, plasma concentration of polymeric (‘labile’) phosphate declined almost exponentially. At best a slight increase in serum orthophosphate concentration (resulting from metaphosphate hydrolysis) was visible. Urinary excretion followed the decline in serum phosphate quite well, the vast majority of metaphosphate was excreted unhydrolysed. - Executive summary:
To study metabolism and urinary excretion of sodium trimetaphosphate, sodium tripolyphosphate, and sodium hexaphosphate, these substances were administered to rabbits. Subsequently, animals were placed in metabolic cages, blood and urine samples were obtained and analysed on orthophosphates and acid-hydrolysable phosphates called ‘labile phosphates’.
After intravenous injection of 249 mg/kg bw trisodium trimetaphosphate into rabbits, plasma concentration of polymeric (‘labile’) phosphate declined almost exponentially. At best a slight increase in serum orthophosphate concentration (resulting from metaphosphate hydrolysis) was visible. Urinary excretion followed the decline in serum phosphate quite well, the vast majority of metaphosphate was excreted unhydrolysed. Alltogether, about 60% of the administered dose was excreted in urine within 3h.
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