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EC number: 701-173-1
CAS number: -
MDI reacts readily with water to form predominantly insoluble and inert polyurea (Yakabe et al 1994) and therefore long-term tests are not appropriate for the derivation of PNEC values. The available chronic Daphnia magna study (OECD 211) indicated no long-term effects after 21 days exposure to 10 mg/L.
test substance is covered by the category approach of methylenediphenyl
diisocyanates (MDI). Hence, data of the category substances can be used
to cover this endpoint. The read-across category justification document
is attached in IUCLID section 13. It is important to note that the MDI
category approach for read-across of environmental and human hazards
between the MDI substances belonging to the MDI category is work in
progress under REACH. Therefore the read-across document should be
considered a draft.
In a semi-static study with Daphnia magna (Caspers et al, 1986)
with PMDI, no long-term toxicity was observed after 21 days exposure to
10 mg/L, which was the highest concentration tested. The test was
carried out according to OECD Guideline 211 and the result was
corroborated by the mesocosm study where no chronic effects were seen to
the zooplankton at loadings of 1000 and 10,000 mg/L.
MDI is rapidly hydrolysed in aqueous solution. However, MDI is
hydrophobic and poorly soluble in water and thus the heterogeneous
reaction with water or soil is less rapid. The major product of such a
reaction is insoluble polyurea (Yakabe et al 1994). Therefore, the
long-term toxicity value is not appropriate to derive PNEC values.
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