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EC number: 300-723-4
CAS number: 127823-21-6
An in vivo skin irritation study with Tricyclodecanemonomethylol
acrylate was performed in rabbits according to OECD 404 and GLP
The skin irritation was not fully reversible within 14 days after
exposure in all 3 animals. Slight oedema (score of 1 or 2) in all three
animals, and slight erythema (score of 1) in one animal were observed at
the end of the observation period. Reduced flexibility and scaliness of
the skin was observed in all three animals during the observation
period. One animal showed bald skin after 14 days.
No staining of the treated skin by the test item was observed and no
test item remnants were seen.
No signs of systemic toxicity were observed in the animals during the
test period and no mortality occurred. No abnormal change of bodyweight
was recorded in the animals.
Based on the persisting skin reactions until day 14 and the 24-72 hours
mean oedema score = 2.3 for all animals: Tricyclodecanemonomethylol
acrylate is classified as a skin irritant.
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