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EC number: 300-723-4
CAS number: 127823-21-6
The objective of this study was to determine
the potential toxicity of Tricyclodecanemonomethylol acrylate,
when given by oral gavage at a single dose to rats of a single sex at
one or more defined doses to evaluate the potential reversibility of any
findings (TG OECD 423). Tricyclodecanemonomethylol acrylate
was administered by oral gavage to two consecutive groups of three
female Wistar rats at 2000 mg/kg body weight. Animals were subjected to
daily observations and weekly determination of body weight. Macroscopic
examination was performed after terminal sacrifice (Day 15).
No mortality occurred. Hunched posture, uncoordinated movements
and/or piloerection were noted on Days 1 and/or 2. The body weight gain
shown by the animals over the study period was considered to be similar
to that expected for normal untreated animals of the same age and
strain. No abnormalities were found at macroscopic post mortem
examination of the animals.
The oral LD50 value of Tricyclodecanemonomethylol acrylate
in Wistar rats was established to exceed 2000 mg/kg body weight.
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