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EC number: 300-723-4
CAS number: 127823-21-6
No experimental toxicokinetic study is available on Tricyclodecanemonomethylol acrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.Based on the toxicological data, QSAR models and the physicochemical properties, the absorption of Tricyclodecanemonomethylol acrylate is expected to be low by oral, dermal route and inhalation.
No experimental toxicokinetic study is available on Tricyclodecanemonomethylol acrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties, including:
-Mean molecular weight: 220 g/mol
-Water solubility: 6.48 mg/L (low solubility)
-Partition coefficient Log Kow: 5,09
-Vapour pressure: 0,0052 Pa
The high value of log Kow (>5) and the low solubility of Tricyclodecanemonomethylol acrylate are not favorable for an oral absorption. Indeed, no clinical effects were observed after one single administration (2000 mg/kg) of Tricyclodecanemonomethylol acrylate by gavage (oral route) in rats. No systemic toxicity was observed during a 14-day repeated-dose toxicity study via the oral, which could only be attributed to absorption of the test item.
A low oral absorption is expected for Tricyclodecanemonomethylol acrylate ; however the worst case value (100%) is used for the risk assessment.
With a low solubility of 6.48 mg/L, dermal absorption is anticipated to be low. With a Log Kow of 5.09, the rate of penetration may be limited by the rate of transfer between the stratum corneum and the epidermis, but uptake into the stratum corneum will be high.
However, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption.
According to the IH skin perm (QSAR), the dermal absorption of Tricyclodecanemonomethylol acrylate is 0 %.
Tricyclodecanemonomethylol acrylate showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose. For the risk assessment, 10% of dermal absorption is taken into account.
Based on the low value of the vapour pressure (<1 Pa), Tricyclodecanemonomethylol acrylate is not considered as a volatile substance.
A low absorption by inhalation is expected for Tricyclodecanemonomethylol acrylate ; however the worst case value (100%) is used for the risk assessment.
DISTRIBUTION and METABOLISM
No specific data is available on the distribution or metabolism of Tricyclodecanemonomethylol acrylate.
Due to the low water solubility and the high log kow, the excretion of Tricyclodecanemonomethylol acrylate in the urines is not expected. An excretion via bile and faeces is possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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