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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Cross-reference
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
sub-chronic toxicity: oral
Type of information:
other: collection of data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
The original study report was not available for preparation of the OECD SIDS document. It is indicated that the study was evaluated by IPCS prior to inclusion in their criteria document (IPCS (1996), Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO Geneva, Switzerland.
Species:
rat
Strain:
Wistar
Sex:
male/female
Route of administration:
oral: drinking water
Duration of treatment / exposure:
9 months
Frequency of treatment:
daily
Dose / conc.:
0.07 other: % in drinking water
Dose / conc.:
0.2 other: % in drinking water
Dose / conc.:
0.6 other: % in drinking water
No. of animals per sex per dose:
8 - 9
Control animals:
yes, concurrent vehicle
Key result
Dose descriptor:
NOAEL
Effect level:
>= 85 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
body weight and weight gain
clinical biochemistry
Remarks on result:
other: NOAEL refers to 0.07% dose group
Key result
Critical effects observed:
yes
Lowest effective dose / conc.:
0.2 other: % in drinking water
System:
hepatobiliary
Organ:
kidney
liver
other: body weight gain
Treatment related:
yes

Data source

Materials and methods

Test material

Test material form:
solid

Results and discussion

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
>= 85 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
body weight and weight gain
clinical biochemistry
Remarks on result:
other: NOAEL refers to 0.07% dose group

Target system / organ toxicity

Key result
Critical effects observed:
yes
Lowest effective dose / conc.:
145 mg/kg bw/day (actual dose received)
System:
hepatobiliary
Organ:
kidney
liver
other: body weight gain
Treatment related:
yes

Applicant's summary and conclusion