Registration Dossier
Registration Dossier
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EC number: 250-001-7 | CAS number: 30007-47-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP and non-guideline compliant study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
- Reference Type:
- publication
- Title:
- Bronidox, a new preserving agent for the cosmetics: properties and toxicological-dermatological assays
- Author:
- M. Potokar, et al.
- Year:
- 1 976
- Bibliographic source:
- Fette, Seifen, Anstrichmittel, Jahrgang 78, Nr. 7, 269-276
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-bromo-5-nitro-1,3-dioxane
- EC Number:
- 250-001-7
- EC Name:
- 5-bromo-5-nitro-1,3-dioxane
- Cas Number:
- 30007-47-7
- Molecular formula:
- C4H6BrNO4
- IUPAC Name:
- 5-bromo-5-nitro-1,3-dioxane
Constituent 1
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Vehicle:
- other: oil in water cream
- Duration of exposure:
- 4 hours
- Doses:
- 0.05%
- Details on study design:
- - Number of probands: 5 probands per dose, no clinical treatment, normal food.
- Age: 27 - 34 years
- Weight: 63 - 83 kg
APPLICATION OF DOSE: 2 g oil/water cream= 1 mg test substance
TEST SITE
- Preparation of test site: on the back
- Area of exposure: 20 x 30 cm
- Control: only vehicle (oil in water cream), next to the treated area
REMOVAL OF TEST SUBSTANCE
- Washing procedures and type of cleansing agent: After 4 hours with alcohol
SAMPLE COLLECTION
- Collection of urine: 1, 2, 3, 4, 8 and 24 hours
ANALYSIS
- Method type(s) for identification: GC of the washed test substance
Results and discussion
Percutaneous absorption
- Key result
- Time point:
- 24 h
- Dose:
- 0.05%
- Parameter:
- percentage
- Absorption:
- ca. 50 %
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
