(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

Boiling point

Administrative data

Endpoint:

boiling point

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is a solid which decomposes before boiling

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 03 January 2018 to 31 January 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

194.5 °C

Decomposition:

yes

Decomp. temp.:

195 °C

Remarks on result:

other: Decomposition started during melting.

DSC EXPERIMENT 1

Endothermic peak between 175°C and 200°C (extrapolated onset temperature: 194.505°C) directly followed by an exothermic effect starting at 200°C. The endothermic effect was most likely obtained due to melting of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a dark brown molten residue remained in the sample container (original colour: light tan). 

DSC EXPERIMENT 2

In order to investigate the melting peak, Experiment 2 was stopped directly after the endothermic peak.  Extrapolated onset temperature: 194.545°C. After the experiment, a light yellow molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item. 

 

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

Conclusions:

The melting temperature of the substance was determined to be 194.5°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 194.5°C. Reaction and/or decomposition of the substance started during melting.