Registration Dossier
Registration Dossier
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EC number: 208-816-0 | CAS number: 542-52-9
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Dibutyl carbonate
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- Dibutyl carbonate
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence (screening)
In a GLP guideline study according to OECD 301F, 60 -70% degradation of the registration item was observed after 28days. Therefore, the test substance is considered biodegradable, but not readily biodegradable (according to OECD criteria). On this basis the substance does not fulfill the criteria for persistence in the environment.
Bioaccumulation (screening)
In a GLP guideline study according to OECD 117, the log Kow of the substance is 3.2 at 23 °C and pH = 6.1 (pH value of the water used for the preparation of the eluent). Therefore the substance is not considered to be bioaccumulative.
Toxicity (screening)
Mammalian Toxicity
Acute oral toxicity of the substance to the rat is >2000 mg/kg and is therefore considered not acutely toxic.
The registered substance did not induce gene mutations in bacteria in an AMES test and is therefore considered non-mutagenic.
The substance is not considered to fulfill the criteria as CMR.
Aquatic Toxicity
No data on the acute toxicity to fish are available for the registration item. In a GLP guideline study according to OECD 202, an EC50 (48h) = 68.5 mg/L was observed. Furthermore, a GLP guideline study on algae showed effect values of ECr50 (72h) = 10.2 mg/L and ECr10 (72h) = 5.4 mg/L, respectively. Based on the data available, the registration item is considered to be acutely harmful to aquatic organisms. The acute L(E)C50 values are above the screening level trigger for T (<0.01 mg/L) so the substance does not meet the criteria for T.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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