Cyclopropanecarboxylic acid, [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-[(cyclopropylcarbonyl)oxy]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl ester

Endpoint summary

Description of key information

Short-term toxicity to fish

Freshwater: 

In a 96 hours semi-static acute toxicity study test (Eco-Science Corporation, SG-ES2011-B05C, 2011) with Cyprinus carpio the LC50 for the test substance was determined to be 18 mg/L based on the nominal concentrations.

 

Marine Water:

In a 96 hours static acute toxicity study (Wildlife International, 394396, 2012) with juvenile sheepshead minnow the LC50 (96 h) for the test substance was determined to be > 31 mg/L, the highest concentration tested, based on the mean measured concentrations. The 96-hour NOEC was 31 mg/L, based on mean measured concentration.

 

Long-term toxicity to fish

Freshwater: 

In a 33-day early life-stage test (BASF SE, 394404, 2015) with Pimephales promelas the NOEC of the test substance for growth was determined to be 0.297 mg/L, based on nominal concentration. The EC10 value was determined to be 0.452 mg/L (nominal concentration).

 

Marine Water:

In a 34-day early life-stage key test (BASF SE, 394404, 2015) with Cyprinodon variegatus the overall NOEC of the test substance for growth was determined to be 0.082 mg/L, based on mean measured concentration. The EC10 value was determined to be 0.071 mg/L (mean measured concentration).

 

 

Short-term to aquatic invertebrates

Freshwater

In a 48-h static acute toxicity study (Eco-Science Corporation, SG-ES2011-B05D, 2011) with Daphnia magna the EC50 of the test substance was determined to be 8.0 mg/L (mean measured).

 

Marine water:

In a 96-hour acute toxicity laboratory key study (Wildlife International, 394392, 2012) according to EPA OPPTS 850.1025 (Bivalve Acute Toxicity (shell deposition test), 1996) the effect of the test substance on shell deposition of eastern oysters (Crassostrea virginica) was investigated. The 96-hour EC50 based on comparison to the negative control was calculated to be 2.17 mg/L (mean measured).

 

Long-term to aquatic invertebrates

Freshwater:

In a 7-day flow-through toxicity laboratory study (ABC Laboratories, 704056, 2014) with Ceriodaphnia dubia the NOEC for the number of live young per surviving adult were 181 ng/L, based on the mean measured concentrations.

 

Marine water:

In a 28-day flow-through toxicity key study (Wildlife International, 394391, 2013) with saltwater mysids (Americamysis bahia) the NOEC, based on reproduction, for the test substance was determined to be 4.0 ng/L, based on mean measured concentrations.

 

Toxicity to algae and cyanobacteria

Freshwater

In a 96-hour algae test (Institute of Industrial Organic Chemistry, 708282, 2014) with Navicula pelliculosa. The 96h-ErC50 of the test substance was determined to be 27.623 mg/L and the 96h-ErC10 was determined to be 15.453 mg/L. These values are based on initial measured test concentrations.

 

Marine water

In a 96-hour algae test (Institute of Industrial Organic Chemistry, 394386, 2014) with Skeletonema costatum, the 96h-ErC50 of the test substance was determined to be 9.921 mg/L and the 96h-ErC10 was determined to be 2.451 mg/L. These values are based on measured concentrations.

 

Toxicity to aquatic plants other than alga

In a static toxicity key study (Institute of Industrial Organic Chemistry, 708271, 2014) with Lemna gibba the 7 d-NOEC was determined to be 2.01 mg/L and the 7d-ErC50 was determined to be 26.20 mg/L based on measured concentration.

 

Toxicity to microorganisms