Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Neurotoxicity
Administrative data
Description of key information
OECD 422; rat; NOAEL (neurotoxicity) = 800 mg/kg (highest dose level tested). Reliability = 1
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 800 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test according to OECD Guideline 422 was conducted in rats at dose levels of 0, 10, 50, 200, or 800 mg/kg/day. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 800 mg/kg/day of the test substance.
Justification for classification or non-classification
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