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EC number: -
CAS number: -
OECD 422; rat; NOAEL (neurotoxicity) = 800 mg/kg (highest dose level tested). Reliability = 1
combined repeated dose feeding toxicity study with the
reproduction/developmental toxicity screening test according to OECD
Guideline 422 was conducted in rats at dose levels of 0, 10, 50, 200, or
800 mg/kg/day. An abbreviated neurobehavioral evaluation consisting of a
functional observational battery and motor activity was conducted in P1 rats
once during pretest and again near the end of the premating period.
There were no test substance-related effects on any neurobehavioral
parameters evaluated in male or female rats administered up to 800
mg/kg/day of the test substance.
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