Registration Dossier
Registration Dossier
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EC number: 209-406-4 | CAS number: 577-11-7
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Remarks:
- other: QSAR (KOCWIN v.2.00)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- NA
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR calculation of KOC, using EPIWIN module KOCWIN (v2.00)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- General model of KOC estimates of chemicals using Log Kow
- Type:
- Koc
- Value:
- 952.3
- Remarks on result:
- other: L/kg
- Type:
- log Koc
- Value:
- 2.979
- Conclusions:
- The Koc value as calculated by using the KOCWIN v2.00 module of EPIWIN 4.0 - is 952.3 L/kg
- Executive summary:
EPIWIN 4.0. calculations result in a KOC of 952.3 l/kg, based on the log Pow of 3.95, as calculated by the KOWWIN module of EPIWIN 4.0 (see see. It is appropriate to use the Log Kow value of 3.95, since log Kow falls within the applicability domain of the EPIWIN model.
Reference
Description of key information
The Koc value was calculated using EPIWIN 4.0. The resulting value of 952.3 L/kg indicates that Docusate Sodium would not strongly adsorb to soils or sediments should these environmental compartments be exposed to it.
Key value for chemical safety assessment
- Koc at 20 °C:
- 952.3
Additional information
The QSAR tool EPIWIN 4.0 was applied to calculate the Koc of Docusate Sodium, based on its Log Kow (EPINWIN 4.0). The resulting Koc estimate of 952.3 L/kg indicates that Docusate Sodium would not strongly adsorb to soils or sediments.
It should be mentioned that, in accordance with EC 1907/2006, Annex VIII, point 9.3.1, column 2, assessment of the adsorption/desorption behaviour of Docusate Sodium is not required due to its ready biodegradability and its low octanol-water partition coefficient, indicating that it has not a high potential to adsorb to soils/sediments. Hence, environmental exposure assessment is not being done. Although determination of Kd/Kocis not required, Koc is needed for PNEC sediment and soil derivation and was hence calculated for that purpose.
[LogKoc: 2.979]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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