Registration Dossier
Registration Dossier
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EC number: 209-406-4 | CAS number: 577-11-7
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- March - April 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: calculations were performed using an established QSAR tool
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: QSAR calculation
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: calculated using the modified Grain method
- Transition / decomposition:
- yes
- Transition temp.:
- > 200 °C
- Executive summary:
Salts have extremely low vapour pressure. Therefore, experimental determination was not possible.
Docusate Sodium is a salt. From salts it is known that they have very low vapour pressures. Docusate Sodium starts loosing volatile components already at 60°C and decomposes at > 200°C. Therefore, the vapour pressure was calculated using EPIWIN 4.00 with the module MPBPVP (v1.43). The calculated vapour pressure is 1.63 · 10-12Pa (Modified Grain method).
Since Docusate Sodium is a salt, a low value was expected and hence the value is considered relevant and reliable for the further risk assessment.
Reference
Description of key information
The calculated vapour pressure is 1.63 * 10-12 Pa
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
Docusate Sodium is a salt. From salts it is known that they have very low vapour pressures making the practical determination of its vapour pressures experimentally very difficult and often not possible.
In the Klimisch 2 key study from Holzschuh (2010) Docusate Sodium starts loosing volatile components at 60°C and decomposes at > 200°C. In the light of the expected low vapour pressure, this made the experimental determination impossible. Therefore, the vapour pressure was calculated using EPIWIN 4.00 with the module MPBPVP (v1.43). The calculated vapour pressure is 1.63 · 10-12Pa (Modified Grain method).
Since Docusate Sodium is a salt, a low value was expected and hence the calculated value of 1.63*10 -12 Pa is considered relevant and reliable for the further risk assessment.
The field "Value used for the CSA" in this endpoint summary does not allow entering values lower than 0.000000001 Pa (=10 -9 Pa). Therefore, a worst case value of 0.000000001 Pa was entered in this field for completeness.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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