Registration Dossier
Registration Dossier
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EC number: 201-607-5 | CAS number: 85-44-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Exxon (Chemical Hazard Data Sheet: Phthalic Anhydride, Number HDHE-F-00026,
- Year:
- 1 996
- Bibliographic source:
- cited in Ridgway P. MorrisL,Ogunbiyi AO, Brown RH, and Cocker J. Acid Anhydrides: Criteria document for an occupational exposure limit. HSE Books, ISBN 0 7176 1059.
Materials and methods
- Principles of method if other than guideline:
- Method: not specified
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
Any other information on results incl. tables
Severe skin irritation was seen following 24 hour exposure.
Skin changes included pale red erythema and superficial 2nd degree
burns. Superficial escharosis and slight to moderate desquamation
observed at 7 and 14 days.
Applicant's summary and conclusion
- Executive summary:
LD50 > 3160 mg/kg bw (rabbit); severe irritation was seen following 24 hour exposure.
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