Registration Dossier
Registration Dossier
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EC number: 201-607-5 | CAS number: 85-44-9
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- publication
- Title:
- In vitro demonstartion of specific IgE in phthalic anhydride hypersensitivity
- Author:
- Maccia CA, Bernstein IL, Emmett EA, Brook SM
- Year:
- 1 976
- Bibliographic source:
- Am. Rev. Respir. Dis. 113, 701-704.
Materials and methods
- Type of study / information:
- Type of experience: other: Biological monitoring at the workplace
- Endpoint addressed:
- repeated dose toxicity: inhalation
- Principles of method if other than guideline:
- A 38-year old chemical foreman noted symptoms of rhinorrhea, postnasal drip, and wheezing several months after he was transferred to a plant which phthalic anhydride (PA) was used as a reagent
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Method
- Details on study design:
- Physical examination, skin tests, radioimmuno assay, bronchial challenge tests were performed
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Phthalic anhydride specific immunoglobin E (IgE) was detected by a radio-allergosorbent test (RAST) in the serum of a chemical worker with hypersensitivity to phthalic anhydride
Any other information on results incl. tables
Positive skin tests, provocative bronchial challenges, and a high serum titer of specific IgE to phthalic anhydride corroborated his clinical hypersensitivity.
Applicant's summary and conclusion
- Executive summary:
A 38-year old chemical foreman noted symptoms of rhinorrhea, postnasal drip, and wheezing several months after he was transferred to a plant which phthalic anhydride (PA) was used as a reagent.
Positive skin tests, provocative bronchial challenges, and a high serum titer of specific IgE to phthalic anhydride corroborated his clinical hypersensitivity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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