Registration Dossier
Registration Dossier
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EC number: 203-812-5 | CAS number: 110-88-3
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity studies on all three trophic levels are available. The results indicate that 1,3,5-trioxane cause no acute toxicity on these trophic levels. For the fresh water fish Leuciscus idus a LC50 (96h) of 4000 mg/L (nominal) and for salt water species (Cyprinodon variegatus) a LC50 (96 h) of 16350 mg/L was reported. No toxicity to Daphnia magna in the highest test concentration (1000 mg/L) was measured. Based on the growth rate the EC50 (72 h) for algae (Scenedesmus subspicatus) was determined to be >500 mg/L. No studies on chronic toxicity to fish and aquatic invertebrates are available. However, in Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity to fish or aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of 1,3,5-trioxane reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Moreover, since trioxane shows an unspecific mode of action a EpiWin v4.00 EcoSAR v1.00 calculation was conducted to estimate the chronic toxicity to fish. The result of this calculation showed no chronic toxicity to fish (ChV > 1000 mg/L). Therefore, long-term toxicity tests neither in fish nor in aquatic invertebrates are provided.
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