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EC number: 203-812-5
CAS number: 110-88-3
LD50 oral >3200 mg/kg bw (no mortalities and no severe signs of toxicity were observed up to the highest dose tested) LC50 inhal. >39.2 mg/l (no mortality and only mild signs of toxicity at maximally achievable vapor concentration)LD50 dermal >3980 mg/kg bw (no clinical symptoms of toxicity)
According to an old but well performed industrial hygiene test no
classification for acute oral toxicity is indicated (BASF AG, 1968). In
rats no mortalities and no severe signs of toxicity were observed up to
the highest dose tested (3200 mg/kg bw).
This data was confirmed by additional incompletely reported studies
(LD50 >5000 mg/kg bw, Celanese 1962; LD50 approx. 8500 mg/kg bw,
Czajkowska et al. 1985).
No mortality and only mild signs of toxicity (secretion, respiratory
distress, poor condition and mild loss of body weight) were observed at
the maximally achievable vapor concentration of 39.2 mg/l (Bio/Dynamics
Inc., 1986). The whole body of rats was exposed and the test atmosphere
was analytically characterized.
(The calculated saturated vapor concentration is 0.0412 x 90 g/mol x
11hPa = 40.1 mg/l.)
Accordingly, further inhalation risk tests did not indicate signs of
toxicity following exposure to vapor atmospheres of 26 mg/l (Czajkowska
et al., 1987) or 22 mg/l air (BASF AG, 1968). No analysis of the test
atmosphere was performed in these assays.
Based on this information no classification is warranted since no
significant signs of toxicity were observed when tested above the limit
dose for GHS Cat.4 (20mg/l for vapor).
Acute toxicity dermal:
No clinical symptoms of toxicity were observed following single dermal
application of 3980 mg/kg bw trioxane for 24 h to male rats (IHFA,
1962). Slight to moderate skin irritation (erythema) was observed
but no classification is indicated.
Similarly no acute dermal toxicity in rats (LD50 >15000mg/kg bw) was
reported in an incompletely reported czech study (Czajkowska et al.,
No mortality or significant signs of toxicity were observed at the
guidance values for all routes of exposure according to Directive
67/548/EEC or Directive 1272/2008.
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