Registration Dossier
Registration Dossier
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EC number: 240-347-7 | CAS number: 16219-75-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In this approved study conducted under GLP, 5-ethylidene-norborn-2-ene was shown to be a sensitizer at 50% v/v and neat. The result suggest that ENB is a weak sensitiser.
Justification for selection of skin sensitisation endpoint:
Only study available.
Justification for classification or non-classification
The results from a mouse LLNA study indicate that ENB should be classified as a skin sensitiser. According to the classification criteria of regulation 286/2011, which amended regulation 1272/2008, an EC3 value of >2% would indicate classification as a weak sensitiser (category 1B). The quantitative data indicate that the response is very weak, with the EC3 value actually being >40%. According to the recommendations of ECETOC ("Contact Sensitisation: Classification according to potency", Technical Report 87, 2003) such a weak response would justify a classification limit for mixtures of 3% rather than the default of 1% and this is proposed for classification purposes.
There is no data on respiratory sensitisation.
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