Registration Dossier
Registration Dossier
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EC number: 233-113-0 | CAS number: 10035-10-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- March 15 to July 5, 1996
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Full study not yet available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- Phosphorus tribromide
- EC Number:
- 232-178-2
- EC Name:
- Phosphorus tribromide
- Cas Number:
- 7789-60-8
- IUPAC Name:
- phosphorus(3+) tribromide
Constituent 1
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: unspecified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
Applicant's summary and conclusion
- Conclusions:
- Genotoxicity testing of bacterial Salmonella strains indicated that PBr3 is not a mutagen for both frame shift and base-pair substitution tester strains in both buffered and unbuffered solutions. PBr3 reacts with moisture to form HBr and phosphonic acid. Thus, it is not likely that HBr is a bacterial mutagen.
- Executive summary:
Genotoxicity testing of bacterial Salmonella strains indicated that PBr3 is not a mutagen for both frame shift and base-pair substitution tester strains in both buffered and unbuffered solutions. PBr3 reacts with moisture to form HBr and phosphonic acid. Thus, it is not likely that HBr is a bacterial mutagen.
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