Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
A study for acute toxicity by the dermal route of gaseous HBr or hydrobromic acid is not justified as the substance is corrosive, and sufficient information is available for the inhalation route.
Executive summary:
According to the Annex VIII Standard Information Requirements for REACH, .an acute toxicity test by the dermal route is required. A specific rule for adaptation (Column 2) for the acute dermal test states that the study (ies) do not need to be conducted if inhalation of the substance is unlikely, skin contact during production is likely, and the physicochemical and toxicological properties suggest a potential for a significant rate of absorption through the skin.

Also in Annex VII, a specific rule for adaptation (Column 2) for acute oral toxicity in the 8.5 series states that the need for a second study by another route is based on potential route of human exposure. If there is only one route of exposure, information for only that route need be provided.

In case of release of hydrogen bromide (HBr) gas or a spill of liquid hydrogen bromide, exposure by inhalation is likely as the material would volatilize. Skin contact during production is not likely because of production in closed systems. Toxicological studies have shown that HBr gas and hydrobromic acid (the strong mineral acid formed by hydrogen bromide in water) are well known to cause burns to skin and eyes. This fact is reflected in the EU classification and labelling of HBr and hydrobromic acid as it is classified/labelled with the symbols “C” and “Xi” and the risk phrases “R35” and “R37”.  As sufficient acute toxicity data by the inhalation route is available for classification, it is not scientifically justified to conduct this test by the dermal route.

Thus, exposure of mammalian species to HBr or hydrobromic acid by the dermal route would not generate meaningful data, and it is not necessary to conduct the acute dermal toxicity test.