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EC number: 201-279-3 | CAS number: 80-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Dicumyl peroxide showed no effects up to maximal water soluble concentrations.
Key value for chemical safety assessment
Additional information
Data on acute toxicity towards fish gave different results based on the fact if solvents were used to prepare stock solution for testing or not. Water solubility of dicumyl peroxide has been determined to be 0.43 mg/L.
In a 96-h acute toxicity study, medaka fisch (Oryzias latipes) were exposed to dicumyl peroxide under semi-static conditions. The test concentrations were prepared using rather high concentrations of solvent and were verified by HPLC analysis. The 96-h LC50 was 0.469 mg/L, slightly above normal water solubility. No mortality has been observed at concentrations of 0.386 mg/L. As the test was performed with solvent the result cannot be regarded as valid for classification and labeling purposes.
Other studies on acute fish toxicity were performed without analytical monitoring.
One of these studies was conducted in accordance with Japanese Industrial Standard JIS K 0102-1986-71 Testing methods for industrial waste water. The 48 h LC50 was determined to be 4.2 mg/L (nominal). The reliability of the study was considered not to be assignable, due to missing information on preparation of test solution and analytical monitoring.
A further study was conducted in accordance with the accepted OECD test guideline 203: fish, acute toxicity test (1984). The LC50 of 108.45 mg/L (95% CL = 80.51-146.07 mg/L) calculated in the report should be used with care as there was no true concentration effect relationship. Test solutions of 10 and 21 mg/L have been prepared by using an acetonic stock solution (max. concentration 100 µL/L), while the higher concentration were obtained by direct addition of substance. Afterwards the solutions were stirred for 24 h. During the test, the substance remained visible at the surface of the test media as a fine layer of solids at all test concentrations. Effects may be caused either by exposure to the concentrations of test substance dissolved in water or via contact or ingestion of particles of the test substance.
However, the import result for classification and labelling purpose is that even with solvent no mortality was observed up to 10 mg/L (in both tests only 1 of 10 animals died at this concentration). In the main test 50 % died at 21 mg/L after 96 h.
In conclusion, data from acute toxicity testing towards fish can be interpreted in a weight of evidence that dicumyl peroxide showed no effects up to maximal water soluble concentrations. This is in line with a recent study on acute toxicity towards daphnia, where no effects were observed in water accommodated fraction (test solution prepared without solvent, but reaching maximal water solubility).
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